Natural Products Originated from the Oxidative Coupling of Tyrosine and Tryptophan: Biosynthesis and Bioinspired Synthesis

The oxidative coupling of tyrosine and tryptophan units is a pivotal step in the total synthesis of some peptide-derived marine and terrestrial natural products, such as the diazonamides, azonazine and tryptorubin A. This Minireview details the biosynthesis and bioinspired synthesis of natural products with such structures. A special focus is put on the challenges of the synthesis of these natural products and the innovative solutions adopted by synthetic chemists.

Automated summary

The oxidative coupling of tyrosine and tryptophan units plays a crucial role in the total synthesis of certain peptide-derived marine and terrestrial natural products such as diazonamides, azonazine, and tryptorubin A. This Minireview focuses on the biosynthesis and bioinspired synthesis of natural products with these structures, highlighting the challenges and innovative solutions adopted by synthetic chemists in their synthesis.