期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 67, 页码 15505-15508出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202003700
关键词
flow chemistry; multi-dimensional chromatography; multiple critical quality attributes; warfarin
资金
- NSERC Canada
- Eli Lilly Research Award Program (LRAP)
Optimization of the asymmetric synthesis of warfarin, an important anticoagulant, has been evaluated using a reconfigurable reaction platform capable of performing batch, continuous flow, and plug-flow synthesis. Further, this platform has been integrated with a novel, multidimensional, multiple variable analysis tool that can evaluate multiple critical quality attributes (CQA), percent conversion and enantiomeric excess in this case, from a single injection that is repeatedly recycled in a closed loop of chromatography columns, a detector and a heart-cut valve. Further, the new, integrated analysis system also facilitates validation of each QA, providing a high-level of confidence in analytical measurements, which are obtained without operator intervention.
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