4.6 Article

The Synthesis of Warfarin Using a Reconfigurable-Reactor Platform Integrated to a Multiple-Variable Optimization Tool

期刊

CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 67, 页码 15505-15508

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202003700

关键词

flow chemistry; multi-dimensional chromatography; multiple critical quality attributes; warfarin

资金

  1. NSERC Canada
  2. Eli Lilly Research Award Program (LRAP)

向作者/读者索取更多资源

Optimization of the asymmetric synthesis of warfarin, an important anticoagulant, has been evaluated using a reconfigurable reaction platform capable of performing batch, continuous flow, and plug-flow synthesis. Further, this platform has been integrated with a novel, multidimensional, multiple variable analysis tool that can evaluate multiple critical quality attributes (CQA), percent conversion and enantiomeric excess in this case, from a single injection that is repeatedly recycled in a closed loop of chromatography columns, a detector and a heart-cut valve. Further, the new, integrated analysis system also facilitates validation of each QA, providing a high-level of confidence in analytical measurements, which are obtained without operator intervention.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据