Degradation of spiramycin by thermally activated peroxydisulfate: Kinetics study, oxidation products and acute toxicity

In recent years, antibiotic residues are frequently detected worldwide that has posed a serious threat to drinking water and increased the risk of bacterial resistance. Sulfate radical (SO4 center dot-)-based advanced oxidation has been regarded as an effective technology for refractory organic pollutants treatment. In this study, the degradation kinetics and mechanism of spiramycin (SPM) under thermally activated peroxydisulfate (PDS) oxidation process in aqueous solution were investigated for the first time. The results indicated that the degradation rate of SPM could be expressed as the kinetic rate equation -d[SPM]/dt=(2.96 x 10(-2) mM(0) min(-1))[SPM](0)[SPM](1) within limited experimental conditions utilized here (i.e., 50 degrees C, pH 7, SPM 0.01-0.05 mM, and K2S2O8 1.0-2.72 mM). The apparent activation energy of 83.27 kJ center dot mol 1 was calculated by Arrhenius equation. The SPM degradation rate decreased with the increase of pH value. The SO4 center dot- and hydroxyl radical (center dot OH) were proved to be the dominant reactive species, but the contribution of SO4 center dot- on the SPM oxidation gradually decreased with the increase of pH value. The presence of humic acid (HA) and inorganic anions negatively affected the SPM degradation. To investigate the possible reaction pathways of SPM under thermally activated PDS system, HPLC/ ESI-QqQMS was employed to identify the intermediate products. In addition, the acute toxicity evaluated by Vibrio fischeri showed that the oxidation byproducts of SPM were not antibacterial. In summary, this study confirmed that the thermally activated PDS technology could be a promising, efficient, and environmentalfriendly approach for removing SPM in aqueous solution.

Automated summary

The study investigated the degradation kinetics and mechanisms of spiramycin under thermally activated peroxydisulfate oxidation process in aqueous solution. It was found that the degradation rate of spiramycin could be expressed by a kinetic rate equation. Sulfate radical and hydroxyl radical were identified as the dominant reactive species, with the former's contribution decreasing with an increase in pH value. Additionally, the presence of humic acid and inorganic anions negatively impacted the degradation of spiramycin.