Recoverable peroxidase-like Fe3O4@MoS2-Ag nanozyme with enhanced antibacterial ability

Antibacterial agents with enzyme-like properties and bacteria-binding ability have provided an alternative method to efficiently disinfect drug-resistance microorganism. Herein, a Fe3O4@MoS2-Ag nanozyme with defect rich rough surface was constructed by a simple hydrothermal method and in-situ photodeposition of Ag nano particles. The nanozyme exhibited good antibacterial performance against E. coli (-69.4%) by the generated ROS and released Ag+, while the nanozyme could further achieve an excellent synergistic disinfection (-100%) by combining with the near-infrared photothermal property of Fe3O4@MoS2-Ag. The antibacterial mechanism study showed that the antibacterial process was determined by the collaborative work of peroxidase-like activity, photothermal effect and leakage of Ag+. The defect-rich rough surface of MoS2 layers facilitated the capture of bacteria, which enhanced the accurate and rapid attack of (OH)-O-center dot and Ag+ to the membrane of E. coli with the assistance of local hyperthermia. This method showed broad-spectrum antibacterial performance against Gramnegative bacteria, Gram-positive bacteria, drug-resistant bacteria and fungal bacteria. Meanwhile, the magnetism of Fe3O4 was used to recycle the nanozyme. This work showed great potential of engineered nanozymes for efficient disinfection treatment.

Automated summary

The study successfully demonstrated the efficient antibacterial performance of Fe3O4@MoS2-Ag nanozyme against E. coli, and revealed a synergistic disinfection effect. Through the collaborative work of peroxidase-like activity, photothermal effect, and Ag+ leakage, the nanozyme could accurately and rapidly attack bacterial membranes, showing broad-spectrum antibacterial capabilities.