期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 97, 期 3, 页码 628-632出版社
WILEY
DOI: 10.1111/cbdd.13798
关键词
antioxidant activities; mechanisms; polysaccharide; traditional Chinese medicine
资金
- key project of science and technology research program of Chongqing Education Commission of China [KJZD-K202000503]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2015-1098]
- Chongqing Key Research Project of Basic Science & Frontier TechnologyChongqing Key Research Project of Basic Science & Frontier Technology [cstc2017jcyjBX0012]
Polysaccharides, as effective components of traditional Chinese medicine, have antioxidant, antiviral, and immunity-enhancing activities. Studies have shown that polysaccharides reduce oxidative stress injury by regulating the expression of antioxidant enzymes and inhibiting NO production.
Polysaccharide, as one of the effective components of traditional Chinese medicine, has the activities of anti-oxidation, anti-virus, improving immunity and so on. Chinese herbal polysaccharides have a wide range of sources. It is found that polysaccharides in many plants and microorganisms have significant antioxidant effects, mainly through the endogenous antioxidant stress Nrf2/ARE pathway to regulate the expression of downstream antioxidant enzymes. These antioxidant enzymes can further block the free radical chain reaction, thus reducing the generation of free radicals. Secondly, by inhibiting the expression of iNOS mRNA and reducing NO production, it can significantly increase the antioxidant capacity and reduce oxidative stress injury. Polysaccharides are rich in natural resources, their multi-channel, multi-target, multi-effect, and other characteristics have made great progress in antioxidants.
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