Developments in Mannose-Based Treatments for Uropathogenic Escherichia coli-Induced Urinary Tract Infections

During their lifetime almost half of women will experience a symptomatic urinary tract infection (UTI) with a further half experiencing a relapse within six months. Currently UTIs are treated with antibiotics, but increasing antibiotic resistance rates highlight the need for new treatments. Uropathogenic Escherichia coli (UPEC) is responsible for the majority of symptomatic UTI cases and thus has become a key pathological target. Adhesion of type one pilus subunit FimH at the surface of UPEC strains to mannose-saturated oligosaccharides located on the urothelium is critical to pathogenesis. Since the identification of FimH as a therapeutic target in the late 1980s, a substantial body of research has been generated focusing on the development of FimH-targeting mannose-based anti-adhesion therapies. In this review we will discuss the design of different classes of these mannose-based compounds and their utility and potential as UPEC therapeutics.

Automated summary

Almost half of women will experience symptomatic UTI during their lifetime, with a high risk of relapse within six months. Current treatment with antibiotics is facing challenges due to increasing resistance rates, leading to a focus on new therapeutic options targeting the uropathogenic Escherichia coli (UPEC). Research on FimH as a therapeutic target has resulted in the development of potential mannose-based anti-adhesion therapies for UPEC.