期刊
CHEMBIOCHEM
卷 22, 期 5, 页码 763-778出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202000372
关键词
bioengineering; bioimaging; biomedical applications; DNA nanotechnology; DNA origami; DNA paint
资金
- European Research Council [340485]
- Human Frontier Science Program [RGP0029-2014]
- Swedish Research Council [K2015-99X-22877-01-6]
- Mizutani Foundation for Glycosciences [200014]
- Agence Nationale pour la Recherche [ANR-16-CE23-0005-02, ANR-19-CE13-0001-01]
- Institut National du Cancer [2018-1-PLBIO-01-ICR-1, 2019-1-PL BIO-05-CEA-1]
- Plan Cancer program LipoCanPredict
- Human Science Frontier Program Organization
- SERB-DST GoI
- Indian Institute of Technology Gandhinagar
- Agence Nationale de la Recherche (ANR) [ANR-19-CE13-0001, ANR-16-CE23-0005] Funding Source: Agence Nationale de la Recherche (ANR)
The field of DNA nanotechnology has branched out into structural, functional, and biologically oriented sub-branches, with a current trend of merging the functionality of DNA devices with the specificity of biomolecules to access a range of functions in biological systems.
The broad field of structural DNA nanotechnology has diverged into various areas of applications ranging from computing, photonics, synthetic biology, and biosensing to in-vivo bioimaging and therapeutic delivery, to name but a few. Though the field began to exploit DNA to build various nanoscale architectures, it has now taken a new path to diverge from structural DNA nanotechnology to functional or applied DNA nanotechnology. More recently a third sub-branch has emerged-biologically oriented DNA nanotechnology, which seeks to explore the functionalities of combinatorial DNA devices in various biological systems. In this review, we summarize the key developments in DNA nanotechnology revealing a current trend that merges the functionality of DNA devices with the specificity of biomolecules to access a range of functions in biological systems. This review seeks to provide a perspective on the evolution and biological applications of DNA nanotechnology, where the integration of DNA structures with biomolecules can now uncover phenomena of interest to biologists and biomedical scientists. Finally, we conclude with the challenges, limitations, and perspectives of DNA nanodevices in fundamental and applied research.
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