4.6 Article

The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits

期刊

CEREBRAL CORTEX
卷 31, 期 1, 页码 281-300

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa225

关键词

claustrum; classical eyeblink conditioning; local field potentials; rabbits; unitary recording; virus-delivered inducible silencing of synaptic transmission

资金

  1. Spanish Ministry of Economy and Competitiveness [BFU2017-82375-R]
  2. Max Planck Society
  3. Charite Postdoctoral Research fellowship
  4. Fritz Thyssen Stiftung
  5. NeuroCure Charite Berlin
  6. Ikerbasque-Basque Foundation of Science
  7. Achucarro Basque Center for Neuroscience
  8. Spanish Ministry of Economy and Business under ERA-NET Neuron

向作者/读者索取更多资源

The claustrum (CL) is believed to be involved in sensorimotor integration and cognitive processes. Through recordings in rabbits during classical eyeblink conditioning, CL neurons were found to be significantly modulated during early sessions of CS/US presentations but not in well-trained animals. The CL appears to play a crucial role in the acquisition of associative learning, particularly in relation to the novelty of CS/US associations.
It is assumed that the claustrum (CL) is involved in sensorimotor integration and cognitive processes. We recorded the firing activity of identified CL neurons during classical eyeblink conditioning in rabbits, using a delay paradigm in which a tone was presented as conditioned stimulus (CS), followed by a corneal air puff as unconditioned stimulus (US). Neurons were identified by their activation from motor (MC), cingulate (CC), and medial prefrontal (mPFC) cortices. CL neurons were rarely activated by single stimuli of any modality. In contrast, their firing was significantly modulated during the first sessions of paired CS/US presentations, but not in well-trained animals. Neuron firing rates did not correlate with the kinematics of conditioned responses (CRs). CL local field potentials (LFPs) changed their spectral power across learning and presented well-differentiated CL-mPFC/CL-MC network dynamics, as shown by crossfrequency spectral measurements. CL electrical stimulation did not evoke eyelid responses, even in trained animals. Silencing of synaptic transmission of CL neurons by the vINSIST method delayed the acquisition of CRs but did not affect their presentation rate. The CL plays an important role in the acquisition of associative learning, mostly in relation to the novelty of CS/US association, but not in the expression of CRs.

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