期刊
CEREBRAL CORTEX
卷 31, 期 1, 页码 694-701出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa253
关键词
electrophysiology; hippocampus; memory disorders; serotonin
资金
- Normandy University
- Normandy Regional Health Agency
Activation of the 5-HT4R has been shown to impact LTP within the hippocampal CA1 area through modulation of GABAergic neurotransmission. The study also revealed the involvement of GABA(B) receptor in this regulatory process.
The type 4 serotonin receptor (5-HT4R) is highly involved in cognitive processes such as learning and memory. Behavioral studies have shown a beneficial effect of its activation and conversely reported memory impairments by its blockade. However, how modulation of 5HT(4)R enables modifications of hippocampal synaptic plasticity remains elusive. To shed light on the mechanisms at work, we investigated the effects of the 5-HT4R agonist RS67333 on long-term potentiation (LTP) within the hippocampal CA1 area. Although high-frequency stimulation-induced LTP remained unaffected by RS67333, the magnitude of LTP induced by theta-burst stimulation was significantly decreased. This effect was blocked by the selective 5-HT4R antagonist RS39604. Further, 5-HT4R-induced decrease in LTP magnitude was fully abolished in the presence of bicuculline, a GABA(A)R antagonist; hence, demonstrating involvement of GABA neurotransmission. In addition, we showed that the application of a GABA(B)R antagonist, CGP55845, mimicked the effect of 5-HT4R activation, whereas concurrent application of CGP55845 and RS67333 did not elicit an additive inhibition effect on LTP. To conclude, through investigation of theta burst induced functional plasticity, we demonstrated an interplay between 5-HT4R activation and GABAergic neurotransmission within the hippocampal CA1 area.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据