期刊
CELLULOSE
卷 27, 期 16, 页码 9181-9199出版社
SPRINGER
DOI: 10.1007/s10570-020-03412-2
关键词
Bacterial cellulose; Enterobacter hormaechei; Response surface methodology; BC composites; Antimicrobial; Characterization
资金
- KLE Technological University, Hubballi
The present investigation reports, the bacterial cellulose (BC) a high-purity polymer produced from isolated strain ZKE7. BC production was optimized by Plackett-Burman and central composite designs yielding 18.5 g/l BC with a 4.5-fold enhancement. BC composites functionalized with antibiotics, BC-gelatin hydrogel, BC-Chitosan hydrogel and BC silver nanoparticle composites were developed and evaluated for water retention capability, moisture content and protein adsorption. The drug release behavior of the composites was consistent for controlled drug delivery. Composites were assessed for functional characteristic such as antimicrobial properties. BC composites functionalized with Neotericine exhibited antifungal activity againstCandida albicans.Other composites showed pronounced antibacterial properties againstEscherichia coli, Bacillus subtilisandMicrococcus luteus.Structural and thermal characterization of BC composites was carried out by FTIR, SEM with energy dispersive X-ray analysis, TGA and differential scanning calorimetry analysis. The results reveal high BC production with excellent properties that can be employed in biomedical field.
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