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IMMUNOBIOLOGY (2009)
Analysis of Cd14 as a Genetic Modifier of Experimental Inflammatory Bowel Disease (IBD) in Mice
Maike F. de Buhr et al.
INFLAMMATORY BOWEL DISEASES (2009)
An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4
Precious G. Motshwene et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
Luigi Franchi et al.
JOURNAL OF IMMUNOLOGY (2009)
TLR4/MyD88/PI3K interactions regulate TLR4 signaling
Michelle H. W. Laird et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2009)
CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation
Erin G. Reed-Geaghan et al.
JOURNAL OF NEUROSCIENCE (2009)
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
Ivan Zanoni et al.
NATURE (2009)
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
Beom Seok Park et al.
NATURE (2009)
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
Eva M. Palsson-McDermott et al.
NATURE IMMUNOLOGY (2009)
Pathways and mechanisms of endocytic recycling
Barth D. Grant et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Screening of innate immune receptors in neurodegenerative diseases: A similar pattern
Maryse Letiembre et al.
NEUROBIOLOGY OF AGING (2009)
Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice
Stefanie Frank et al.
NEUROSCIENCE LETTERS (2009)
Mechanism of glycosaminoglycan-mediated bone and joint disease - Implications for the mucopolysaccharidoses and other connective tissue diseases
Calogera M. Simonaro et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling
Natsuko Tanimura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
LPS/TLR4 signal transduction pathway
Yong-Chen Lu et al.
CYTOKINE (2008)
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Patrice D. Cani et al.
DIABETES (2008)
Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal
Sung-Chun Tang et al.
EXPERIMENTAL NEUROLOGY (2008)
β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes
Melanie J. Scott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7
Raul Rojas et al.
JOURNAL OF CELL BIOLOGY (2008)
Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation
Hua Shen et al.
JOURNAL OF IMMUNOLOGY (2008)
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
Jonathan C. Kagan et al.
NATURE IMMUNOLOGY (2008)
Early Neurodegeneration Progresses Independently of Microglial Activation by Heparan Sulfate in the Brain of Mucopolysaccharidosis IIIB Mice
Jerome Ausseil et al.
PLOS ONE (2008)
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
Koichiro Takahashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms
Hugues Chanteux et al.
RESPIRATORY RESEARCH (2007)
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran
Ho Min Kim et al.
CELL (2007)
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
Yuzhen Wang et al.
BLOOD (2007)
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani et al.
DIABETES (2007)
The MYD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4
Nicola Tamassia et al.
JOURNAL OF IMMUNOLOGY (2007)
Cutting edge: Involvement of the type IIFN production and signaling pathway in lipopolysaccharide-induced IL-10 production
Elmer Y. Chang et al.
JOURNAL OF IMMUNOLOGY (2007)
A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
Baomei Shao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Modulation of innate immune responses with synthetic lipid a derivatives
Yanghui Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: A potential basis for glial cell activation in the NPC brain
Michitaka Suzuki et al.
JOURNAL OF NEUROSCIENCE (2007)
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
Yi Yang et al.
IMMUNITY (2007)
Role of the toll-like receptor 4 in neuro-inflammation in Alzheimer's disease
Silke Walter et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4)
Alberto Visintin et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2006)
Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling
Jonathan C. Kagan et al.
CELL (2006)
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering
Makiko Kobayashi et al.
JOURNAL OF IMMUNOLOGY (2006)
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
DC Rowe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
H Husebye et al.
EMBO JOURNAL (2006)
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
H Häcker et al.
NATURE (2006)
Control of B-cell responses by Toll-like receptors
C Pasare et al.
NATURE (2005)
Rip1 mediates the Trif-dependent Toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation
N Cusson-Hermance et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
DH Jiang et al.
NATURE MEDICINE (2005)
Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex
SC Gangloff et al.
JOURNAL OF IMMUNOLOGY (2005)
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide
Y Liu et al.
BRAIN (2005)
CD14 is required for MyD88-independent LPS signaling
ZF Jiang et al.
NATURE IMMUNOLOGY (2005)
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
WJ Kaiser et al.
JOURNAL OF IMMUNOLOGY (2005)
Crystal structure of CD14 and its implications for lipopolysaccharide signaling
JI Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β
T Hirotani et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Monomeric endotoxin: protein complexes are essential for TLR4-dependent cell activation
TL Gioannini et al.
JOURNAL OF ENDOTOXIN RESEARCH (2005)
Neutrophil extracellular traps kill bacteria
V Brinkmann et al.
SCIENCE (2004)
Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria
H Uronen-Hansson et al.
IMMUNOLOGY (2004)
TLR4 is the signaling but not the lipopolysaccharide uptake receptor
S Dunzendorfer et al.
JOURNAL OF IMMUNOLOGY (2004)
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-dindependent signaling cascades
H Björkbacka et al.
PHYSIOLOGICAL GENOMICS (2004)
Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells
MJ Yang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Toll-like receptors in normal and cystic fibrosis airway epithelial cells
A Muir et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)
The LPS receptor (CD14) links innate immunity with Alzheimer's disease
K Fassbender et al.
FASEB JOURNAL (2004)
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
H Oshiumi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
K Hoebe et al.
NATURE IMMUNOLOGY (2003)
Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-Binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the toll-like receptor signaling
S Sato et al.
JOURNAL OF IMMUNOLOGY (2003)
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
M Yamamoto et al.
SCIENCE (2003)
Lipopolysaccharide (LPS)-binding protein inhibits responses to cell-bound LPS
PA Thompson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells
S Varadaradjalou et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Toll-like receptor expression in murine DC subsets:: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines
AD Edwards et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Inhibition of endotoxin response by E5564, a novel toll-like receptor 4-directed endotoxin antagonist
M Mullarkey et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Activation of lysosomal function during dendritic cell maturation
ES Trombetta et al.
SCIENCE (2003)
Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons
ACE Vreugdenhil et al.
JOURNAL OF IMMUNOLOGY (2003)
Lipopolysaccharide rapidly traffics to and from the golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
E Latz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
T Horng et al.
NATURE (2002)
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
M Yamamoto et al.
NATURE (2002)
Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: A critical role for monocytes in leukocyte lipopolysaccharide responses
I Sabroe et al.
JOURNAL OF IMMUNOLOGY (2002)
Human Toll-like receptor 4 recognizes host-specific LPS modifications
AM Hajjar et al.
NATURE IMMUNOLOGY (2002)
The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes
N Iovine et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution
K Miyake et al.
JOURNAL OF ENDOTOXIN RESEARCH (2002)
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
T Kawai et al.
JOURNAL OF IMMUNOLOGY (2001)
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
KA Fitzgerald et al.
NATURE (2001)
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex - Transfer from CD14 to TLR4 and MD-2
JD Correia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro:: Lipopolysaccharide activation of epithelial cells revisited
DP Funda et al.
INFECTION AND IMMUNITY (2001)
Distribution and kinetics of lipoprotein-bound endotoxin
JHM Levels et al.
INFECTION AND IMMUNITY (2001)
Endotoxin-induced maturation of MyD88-deficient dendritic cells
T Kaisho et al.
JOURNAL OF IMMUNOLOGY (2001)
Transport of peptide-MHC class II complexes in developing dendritic cells
SJ Turley et al.
SCIENCE (2000)
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