期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 78, 期 4, 页码 1369-1392出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03667-9
关键词
Stroke; Alzheimer's disease; Parkinson's disease; Neuroprotection; Macroautophagy; Autophagy receptor
资金
- China Postdoctoral Science Foundation [2017M612010]
- National Natural Science Foundation of China [81701144, 81371433]
- National Key Research and Development Program of China [2017YFC1308500]
- Key Program of Science and Technology Development of Zhejiang [2017C03021]
Autophagy is a fundamental process for clearing misfolded proteins and damaged organelles in cells, closely implicated in neurological diseases. Different types of selective autophagy are controlled by a group of important proteins, including PINK1, Parkin, and others, which are crucial for research on neurological diseases.
The neurological diseases primarily include acute injuries, chronic neurodegeneration, and others (e.g., infectious diseases of the central nervous system). Autophagy is a housekeeping process responsible for the bulk degradation of misfolded protein aggregates and damaged organelles through the lysosomal machinery. Recent studies have suggested that autophagy, particularly selective autophagy, such as mitophagy, pexophagy, ER-phagy, ribophagy, lipophagy, etc., is closely implicated in neurological diseases. These forms of selective autophagy are controlled by a group of important proteins, including PTEN-induced kinase 1 (PINK1), Parkin, p62, optineurin (OPTN), neighbor of BRCA1 gene 1 (NBR1), and nuclear fragile X mental retardation-interacting protein 1 (NUFIP1). This review highlights the characteristics and underlying mechanisms of different types of selective autophagy, and their implications in various forms of neurological diseases.
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