期刊
CELLS TISSUES ORGANS
卷 211, 期 2, 页码 183-192出版社
KARGER
DOI: 10.1159/000511383
关键词
OVOL1; OVOL2; Epithelial-mesenchymal transition; Mesenchymal-epithelial transition; Epithelial differentiation
资金
- Ramanujan Fellowship - Science and Engineering Research Board (SERB)
- Department of Science and Technology (DST), Government of India
- Instituto de Salud Carlos III-FSE
- AECC lab
OVOL proteins play critical roles in epithelial lineage determination and differentiation during embryonic development, cancer progression, and cellular reprogramming.
OVOL proteins (OVOL1 and OVOL2), vertebrate homologs of Drosophila OVO, are critical regulators of epithelial lineage determination and differentiation during embryonic development in tissues such as kidney, skin, mammary epithelia, and testis. OVOL can inhibit epithelial-mesenchymal transition and/or can promote mesenchymal-epithelial transition. Moreover, they can regulate the stemness of cancer cells, thus playing an important role during cancer cell metastasis. Due to their central role in differentiation and maintenance of epithelial lineage, OVOL overexpression has been shown to be capable of reprogramming fibroblasts to epithelial cells. Here, we review the roles of OVOL-mediated epithelial differentiation across multiple contexts, including embryonic development, cancer progression, and cellular reprogramming.
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