期刊
CELL STEM CELL
卷 27, 期 4, 页码 532-556出版社
CELL PRESS
DOI: 10.1016/j.stem.2020.09.011
关键词
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资金
- NIH [R01-AR050452, R01-AR31737, R01-AR27883, R01-AG020961, R01-HG00967401]
- Starr Foundation
- Melanoma Research Alliance
- NYSTEM [C32585GG]
- Baxter Foundation
- Li Ka Shing Foundation
- California Institute for Regenerative Medicine (CIRM) grants [DISC1-10036, DISC2-10604]
- American Heart Association grant [AHA-17CSA33590101]
Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms in communicating with their microenvironmental niche to transition between quiescent and regenerative states. Here we use skin epithelium and skeletal muscle-among the most highly-stressed tissues in our body-to highlight similarities and differences in niche constituents and how SCs mediate natural tissue rejuvenation and perform regenerative acts prompted by injuries. We discuss how these communication networks break down during aging and how understanding tissue SCs has led to major advances in regenerative medicine.
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