期刊
CELL METABOLISM
卷 32, 期 3, 页码 447-+出版社
CELL PRESS
DOI: 10.1016/j.cmet.2020.08.004
关键词
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资金
- Weldon Foundation
- Ponce de Leon Health
- NIH [U01AG045844]
- NIA [R01AG051729]
- Larry L. Hillblom Foundation
- Navigage Foundation
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alphaketoglutarate (delivered in the form of a calciumsalt, CaAKG) on healthspan and lifespan in C57BL/6 mice. To probe the relationship between healthspan and lifespan extension inmammals, we performed a series of longitudinal, clinically relevant measurements. We find that CaAKG promotes a longer, healthier life associated with a decrease in levels of systemic inflammatory cytokines. We propose that induction of IL-10 by dietary AKG suppresses chronic inflammation, leading to health benefits. By simultaneously reducing frailty and enhancing longevity, AKG, at least in the murine model, results in a compression of morbidity.
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