期刊
CELL DEATH AND DIFFERENTIATION
卷 27, 期 11, 页码 2989-3003出版社
SPRINGERNATURE
DOI: 10.1038/s41418-020-00624-8
关键词
-
资金
- National Health & Medical Research Council (NHMRC) [1144500, 1156601]
- NHMRC Senior Principal Research Fellowship [1103006]
- University of South Australia
- National Health and Medical Research Council of Australia [1144500, 1156601] Funding Source: NHMRC
Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to initiate innate immune responses during microbial infections and/or cell death. Several seminal studies over the past decade have delineated the conserved mechanism of cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and the downstream signaling adapter stimulator of interferon genes (STING) in mediating innate immune signaling pathways as a host defense mechanism. Besides the predominant role in microbial infections and inflammatory diseases, there is an increased attention on alternative functional responses of cGAS-STING-mediated signaling. Here we review the complexity of interactions between the cGAS-STING signaling and cell death pathways. A better understanding of molecular mechanisms of this interplay is important with regard to the development of new therapeutics targeting cGAS-STING signaling in cancer, infectious, and chronic inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据