期刊
CELL AND TISSUE RESEARCH
卷 382, 期 1, 页码 161-172出版社
SPRINGER
DOI: 10.1007/s00441-020-03260-3
关键词
Amygdala; LTP; Fear; Extinction; BDNF; GABA
类别
资金
- Projekt DEAL
- Deutsche Forschungsgemeinschaft [SFB 779, TP B6]
- EU Joint Programme - Neurodegenerative Disease Research (JPND) project CIRCPROT - BMBF
- EU Joint Programme - Neurodegenerative Disease Research (JPND) project CIRCPROT - European Union's Horizon 2020 research and innovation program [643417]
- European Regional Development Fund of the initiative Sachsen-Anhalt WISSENSCHAFT Schwerpunkte [ZS/2016/04/78123]
The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据