期刊
CELL
卷 183, 期 4, 页码 996-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.09.038
关键词
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资金
- NIH NIAID, United States [AI142742]
- NIH [75N9301900065]
- NIH NIAID [AI100625, U19 AI118626]
- Bill and Melinda Gates Foundation, United States
- LJI Institutional Funds
- Johnathan and Mary Tu Foundation
- NIAID under K08 award [AI135078]
- NIAID under K99 award [AI145762]
- UCSD T32s Infectious Diseases Division [AI007036, AI007384]
- Therapeutics Accelerator [INV-006133]
- Mastercard
- Wellcome
- Departamento Administrativo de Ciencia, Tecnologia e Innovacion (COLCIENCIAS)
- Pontificia Universidad Javeriana, Colombia (Convocatoria 727 Doctorados Nacionales)
- Bill and Melinda Gates Foundation [INV-006133] Funding Source: Bill and Melinda Gates Foundation
Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4(+) and CD8(+) T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4(+) and CD8(+) T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4(+) and CD8(+) T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals R 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that co-ordinated CD4(+) T cell, CD8(+) T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.
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