期刊
CELL
卷 183, 期 1, 页码 28-45出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.09.014
关键词
-
资金
- Intramural Research Program of the NIH, NCI, Center for Cancer Research
- NIH Common Fund 4D Nucleosome Program [U54 DK107890]
Genomes have complex three-dimensional architectures. The recent convergence of genetic, biochemical, biophysical, and cell biological methods has uncovered several fundamental principles of genome organization. They highlight that genome function is a major driver of genome architecture and that structural features of chromatin act as modulators, rather than binary determinants, of genome activity. The interplay of these principles in the context of self-organization can account for the emergence of structural chromatin features, the diversity and single-cell heterogeneity of nuclear architecture in cell types and tissues, and explains evolutionarily conserved functional features of genomes, including plasticity and robustness.
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