期刊
CELL
卷 183, 期 1, 页码 158-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.08.017
关键词
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资金
- Swedish Research Council
- Karolinska Institutet
- Swedish Society for Medical Research
- Jeansson Stiftelser
- Ake Wibergs Stiftelse
- Swedish Society of Medicine
- Swedish Cancer Society
- Swedish Childhood Cancer Fund
- Magnus Bergvalls Stiftelse
- Hedlunds Stiftelse
- Lars Hiertas Stiftelse
- Swedish Physicians against AIDS Foundation
- Jonas Soderquist Stiftelse
- Clas Groschinskys Minnesfond
- Alice och Knut Wallenbergs Stiftelse
- Nordstjernan AB
- Wellcome Trust [100326/Z/12/Z]
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
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