4.7 Article

Tc17 CD8+ T cells accumulate in murine atherosclerotic lesions, but do not contribute to early atherosclerosis development

期刊

CARDIOVASCULAR RESEARCH
卷 117, 期 14, 页码 2755-2766

出版社

OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvaa286

关键词

CD8 T-cell; Atherosclerosis; IL-17; IFN-gamma

资金

  1. Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation
  2. Dutch Federation of University Medical Centres
  3. Netherlands Organisation for Health Research and Development
  4. Royal Netherlands Academy of Sciences [CVON2011-19]

向作者/读者索取更多资源

In an atherosclerotic mouse model, a lesion-localized increase in Tc17 cells was found. Tc17 cells appeared to be non-atherogenic compared to their Tc0 counterparts.
Aims CD8(+) T cells can differentiate into subpopulations that are characterized by a specific cytokine profile, such as the Tc17 population that produces interleukin-17. The role of this CD8(+) T-cell subset in atherosclerosis remains elusive. In this study, we therefore investigated the contribution of Tc17 cells to the development of atherosclerosis. Methods and results Flow cytometry analysis of atherosclerotic lesions from apolipoprotein E-deficient mice revealed a pronounced increase in ROR gamma t(+)CD8(+) T cells compared to the spleen, indicating a lesion-specific increase in Tc17 cells. To study whether and how the Tc17 subset affects atherosclerosis, we performed an adoptive transfer of Tc17 cells or undifferentiated Tc0 cells into CD8(-/-) low-density lipoprotein receptor-deficient mice fed a Western-type diet. Using flow cytometry, we showed that Tc17 cells retained a high level of interleukin-17A production in vivo. Moreover, Tc17 cells produced lower levels of interferon-gamma than their Tc0 counterparts. Analysis of the aortic root revealed that the transfer of Tc17 cells did not increase atherosclerotic lesion size, in contrast to Tc0-treated mice. Conclusion These findings demonstrate a lesion-localized increase in Tc17 cells in an atherosclerotic mouse model. Tc17 cells appeared to be non-atherogenic, in contrast to their Tc0 counterpart. [GRAPHICS] .

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