期刊
CARBOHYDRATE POLYMERS
卷 245, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116585
关键词
Curdlan; Hydrogel; Polydopamine; Photothermal therapy; Periodontitis
资金
- Zhejiang Provincial Science and Technology Project for Public Welfare [LGF18H140007]
- Wenzhou Medical University [KYYW201901, KYYW201906, KYQD20190513]
- University of Chinese Academy of Science [WIUCASYJ2020001]
- Wenzhou Science and Technology Plan Project [ZY202005]
- Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province [WIBEK181007]
Curdlan, a bacteria-derived polysaccharide resource, possesses substantial potential for periodontal anti-microbial delivery. Here, the facile engineering of a functionalized curdlan/polydopamine (PDA) composite hydrogels was reported. The physiochemical evaluations of composite hydrogels proved their tunable properties associated with concentration of PDA including pore size, rheological property and swelling behavior. We have systematically assessed biocompatibility in vitro and found these hydrogels toxicity-free. Moreover, photo -thermal performance upon near infrared light (NIR) exposure was conducted and eventually indicated the best matches for antibacterial application. The acetate chlorhexidine (CHX) was chosen as a model antimicrobial and the release profiles demonstrated the entrapped CHX could be triggered and nicely controlled by NIR. The optimized bacteriostatic rate reached 99.9 %. Overall, we aimed to provide new curdlan-based hydrogels for antibacterial treatment effect and antimicrobial
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据