期刊
CANCER RESEARCH
卷 81, 期 1, 页码 18-26出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-20-2245
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- China-US (Henan) Hormel Cancer Institute
The role of CDK12 in carcinogenesis and cancer prevention is not well understood, but a comprehensive understanding of CDK12 could greatly facilitate the development of new strategies for cancer treatment and prevention.
Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family of proteins (CDK) and is critical for cancer development. Years of study into CDK12 have generated much information regarding the intricacy of its function and mechanism as well as inhibitors against it for ontological research. However, there remains a lack of understanding regarding the role of CDK12 in carcinogenesis and cancer prevention. An exhaustive comprehension of CDK12 will highly stimulate the development of new strategies for treating and preventing cancer. Here, we review the literature of CDK12, with a focus on its function, its role in signaling, and how to use it as a target for discovery of novel drugs for cancer prevention and therapy.
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