期刊
CANCER LETTERS
卷 489, 期 -, 页码 155-162出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.05.036
关键词
Exosome; Cancer therapeutics; Drug delivery; Bioactive molecules
类别
资金
- National Research Foundation of Korea (NRF) - Korean government [2017R1A3B1023418, 2018H1A2A1062948]
- KIST Institutional Program
- KU-KIST Graduate School of Converging Science and Technology Program
- National Research Foundation of Korea [2018H1A2A1062948] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circulation in vivo. In this review, we cover recent approaches and advances made in the field of exosome-mediated delivery of bioactive molecules for cancer therapy and factors that affect the clinical use of exosomes. This review can be used as a guideline for further study in expanding the utility of therapeutic exosomes.
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