期刊
CANCER LETTERS
卷 489, 期 -, 页码 87-99出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.05.038
关键词
Exosome; miR-1910-3p; Breast cancer; Proliferation; Metastasis
类别
资金
- National Natural Science Foundation of China [81702078]
- Natural Science Foundation of Jiangsu Province [BK20170356]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [17KJB320016]
- Suzhou Science and Technology Project [SYS201728]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_2535]
- Young Stuff Preresearch Fund Project of The Second Affiliated Hospital of Soochow University [SDFEYQN1718]
Exosomes are key mediators of intercellular communication and play a role in the pathogenesis and progression of cancer. Exosomes in circulating body fluids serve as molecular markers for cancer diagnosis. This study aimed to investigate the role of exosomal microRNA (miR)-1910-3p in breast cancer and determine its clinical diagnostic value. MiR-1910-3p promoted proliferation and migration of breast cancer cells in vitro and in vivo. In vitro, exosomes enriched in miR-1910-3p transferred miR-1910-3p to mammary epithelial cells and breast cancer cells, promoting proliferation and migration, inhibiting apoptosis, and inducing autophagy. In vivo, exosomes enriched in miR-1910-3p promoted the proliferation and migration of breast cancer cells. MiR-1910-3p down regulated myotubularin-related protein 3, activated the NF-kappa B and wnt/beta-catenin signaling pathway, and promoted breast cancer progression. Serum miR-1910-3p in exosomes was an effective diagnostic marker that improved the sensitivity of breast cancer diagnosis when used in combination with the traditional tumor marker CA153. In conclusion, breast cancer cell-derived exosomes promoted the growth, metastasis, and autophagy of breast cancer cells by transferring miR-1910-3p. MiR-1910-3p in serum exosomes may serve as a novel molecular marker for breast cancer diagnosis.
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