期刊
CANCER CELL
卷 38, 期 5, 页码 716-+出版社
CELL PRESS
DOI: 10.1016/j.ccell.2020.08.014
关键词
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资金
- Shanghai American School
- Shanghai Hospital Development Center [SHDC12018X22]
- Science Foundation of Shanghai Excellent Youth Scholars [2017YQ042]
- Science Foundation of Shanghai [19411966800]
- New Hundred People Plan of Shanghai Health and Family Planning Commission Foundation [2017 BR052]
- Ministry of Science and Technology of the People's Republic of China [2017YFA0102900]
Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most common extracranial solid tumor occurring in childhood. Despite extensive research, the underlying developmental origin of NB remains unclear. Using single-cell RNA sequencing, we generate transcriptomes of adrenal NB from 160,910 cells of 16 patients and transcriptomes of putative developmental cells of origin of NB from 12,103 cells of early human embryos and fetal adrenal glands at relatively late development stages. We find that most adrenal NB tumor cells transcriptionally mirror noradrenergic chromaffin cells. Malignant states also recapitulate the proliferation/differentiation status of chromaffin cells in the process of normal development. Our findings provide insight into developmental trajectories and cellular states underlying human initiation and progression of NB.
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