期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 178, 期 14, 页码 2863-2879出版社
WILEY
DOI: 10.1111/bph.15245
关键词
coagulopathy; complement activation; complementopathy; organ failure; trauma
资金
- [CRC 1149 A01]
- [INST 40/479-2]
- [INST 40/487-2]
Physical trauma is a significant global burden that can lead to an imbalance in complement activation, which in turn may cause immune dysfunction and organ response impairment. Immunomodulatory approaches have the potential to improve trauma management procedures and enhance patient outcomes by addressing this imbalance.
Physical trauma represents a major global burden. The trauma-induced response, including activation of the innate immune system, strives for regeneration but can also lead to post-traumatic complications. The complement cascade is rapidly activated by damaged tissue, hypoxia, exogenous proteases and others. Activated complement can sense, mark and clear both damaged tissue and pathogens. However, excessive and insufficient activation of complement can result in a dysfunctional immune and organ response. Similar to acute coagulopathy, complementopathy can develop with enhanced anaphylatoxin generation and an impairment of complement effector functions. Various remote organ effects are induced or modulated by complement activation. Frequently, established trauma treatments are double-edged. On one hand, they help stabilising haemodynamics and oxygen supply as well as injured organs and on the other hand, they also drive complement activation. Immunomodulatory approaches aim to reset trauma-induced disbalance of complement activation and thus may change surgical trauma management procedures to improve outcome.
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