期刊
BRITISH JOURNAL OF NUTRITION
卷 125, 期 12, 页码 1386-1393出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114520003633
关键词
Antioxidants; Cows’ milk allergy; Maternal diet; Pregnancy
资金
- Academy of Finland [63672, 79685, 79686, 80846, 201988, 210632, 129492, 126813, 276475]
- Finnish Paediatric Research Foundation
- Juho Vainio Foundation
- Yrjo Jahnsson Foundation
- Tampere University Hospital [9L035, 9M029, 9P017, 9P057, 9R012, 9R055, 9S015, 9S074, 9T072, 9U016, 9U065, 9V012]
- Medical Research Funds of Turku University Hospital
- European Foundation for the Study of Diabetes
- Juvenile Diabetes Research Foundation [197032, 4-1998-274, 4-1999-731, 4-2001-435]
- Novo Nordisk Foundation
- EU Biomed 2 [BMH4-CT98-3314]
- Doctoral Programs for Public Health
- Foundation for Allergy Research
- Research Foundation of Orion Corporation
- Tampere Tuberculosis Foundation
- Paivikki and Sakari Sohlberg foundation
- Jalmari and Rauha Ahokas Foundation
- Medical Research Fund of Oulu University Hospital
- Academy of Finland (AKA) [276475, 276475] Funding Source: Academy of Finland (AKA)
The study found that maternal total and dietary intake of beta-carotene during pregnancy is associated with an increased risk of CMA in offspring. Using dietary supplements containing antioxidants in addition to a balanced diet may not offer any additional benefits.
Cows' milk allergy (CMA) is the most common food allergy in young children, and it is often the first manifestation of atopic diseases. Accordingly, very early environmental factors, such as maternal diet during pregnancy, may play a role in the development of CMA, but the evidence is limited. The aim of this study was to investigate the association between maternal intake of antioxidant nutrients during pregnancy and the subsequent development of CMA in the offspring in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study. Maternal dietary information during pregnancy was collected with a detailed, validated FFQ. The maternal dietary information and the information on putative confounding factors were available for 4403 children. Information on diagnosed CMA (n 448) was obtained from a medical registry and queried from the parents up to child's age of 3 years. The Finnish food composition database was used to calculate the average daily intake of nutrients. Logistic regression was applied for statistical analyses, and the nutrient intakes were adjusted for energy intake. OR are presented per 1 sd increment of the particular nutrient intake. Maternal total and dietary intake of beta-carotene was associated with an increased risk of CMA in the offspring when adjusted for the putative confounding factors (total OR 1 center dot 10, 95 % CI 1 center dot 02, 1 center dot 20; dietary OR 1 center dot 10; 95 % CI 1 center dot 01, 1 center dot 19). Using dietary supplements containing antioxidants in addition to a balanced diet may not confer any additional benefits.
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