期刊
BRACHYTHERAPY
卷 20, 期 1, 页码 185-188出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brachy.2020.07.008
关键词
High-dose-rate interstitial brachytherapy; Keloids; Postoperative radiation
A retrospective study of interstitial high-dose-rate BT treatment of keloids in 14 patients revealed a wide range of target coverage, likely due to the curvature of the skin and challenges in catheter placement. Additional data is needed to evaluate the clinical impact on outcomes/toxicities of dosimetric correlates with single-catheter BT keloid treatment.
PURPOSE: Brachytherapy (BT) after surgical resection of keloids reduces the risk of local recurrence, but standardization of dose/technique is lacking. Typical keloid BT treatment utilizes a single-channel source prescribed to 5-mm depth. We investigated the dosimetry of a volume based target definition for interstitial high-dose-rate BT treatment of keloids. METHODS AND MATERIALS: We retrospectively identified consecutive 14 patients who had a total of 20 keloids treated with interstitial high-dose-rate BT for keloids at our institution between 2004 and 2014. Keloids were treated with a single 8 Gy fraction prescribed to 5 mm beneath the scar within 36 h of surgery. Retrospectively, a 3-mm skin high-risk clinical target volume (HR-CTV) was contoured under the scar for volume-based dose calculations. RESULTS: Mean (SD) HR-CTV was 3.91 cm3 (3.1) and mean (SD) HR-CTV dose was 11.3 Gy (3.6). Mean D-90 (SD) was 62.9% (25.8) and mean V-100 (SD) was 56.5% (26.4). The mean V-150 (SD), V200 (SD), and V-300 (SD) were as follows: 37.6% (19.9), 25.1% (14.4), and 11.3% (6.5), respectively. No local failures were reported at 9 months median followup. There were no Grade 2 or higher late toxicities. CONCLUSIONS: Using a volume-based target definition, a wide range of target coverage was observed. This is likely a consequence of the curvature of the skin and the challenges of keeping the catheter equidistant from the skin across the target. Additional data are needed to define the potential clinical impact on outcomes/toxicities of dosimetric correlates with single-catheter BT keloid treatment. (c) 2021 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
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