期刊
BONE
卷 143, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2020.115609
关键词
Tendon/ligament development; Transcription factor; Signaling pathway; Mechanical stress
资金
- Japan Society for the Promotion of Science [20H00547]
- Japan Agency for Medical Research and Development [JP20gm0810008]
- National Institutes of Health [AR050631, AR065379]
- Grants-in-Aid for Scientific Research [20H00547] Funding Source: KAKEN
This review discusses the core molecular mechanisms involved in the development and homeostasis of tendons and ligaments, with a particular focus on transcription factors, signaling pathways, and mechanical stress.
Tendons transmit power from muscles to bones, and ligaments maintain the stability of joints, thus producing smooth and flexible movements of articular joints. However, tendons have poor self-healing ability upon damage due to injuries, diseases, or aging. To maintain homeostasis or promote regeneration of the tendon/ligament, it is critical to understand the mechanism responsible for the coordination of tendon/ligament-specific gene expression and subsequent cell differentiation. In this review, we have discussed the core molecular mechanisms involved in the development and homeostasis of tendons and ligaments, with particular focus on transcription factors, signaling, and mechanical stress.
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