期刊
BMC NEUROLOGY
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12883-020-01924-9
关键词
Coma-recovery scale-revised; Disorders of consciousness; Unresponsive wakefulness syndrome; Minimally conscious state; Misdiagnosis
资金
- National Natural Science Foundation of China [81471100, 811247008, 81920108023]
- National High Technology Research and Development Program of China [2015AA020514]
- Hangzhou Normal University [2018PYXML007]
- Zhejiang Province Chinese Medicine Science and Technology Program Project [2018ZB101]
- Zhejiang Basic Public Interest Research Program Project [LGF20H090017]
- European Union [785907]
- fund Generet
- King Baudouin Foundation
- DOCMA project (EU-H2020-MSCA) [RISE778234]
Background: Previous studies have shown that a single Coma-Recovery Scale-Revision (CRS-R) assessment can identify high rates of misdiagnosis by clinical consensus. The aim of this study was to investigate the proportion of misdiagnosis by clinical consensus compared to repeated behavior-scale assessments in patients with prolonged disorders of consciousness (DOC). Methods: Patients with prolonged DOC during hospitalization were screened by clinicians, and the clinicians formed a clinical-consensus diagnosis. Trained professionals used the CRS-R to evaluate the consciousness levels of the enrolled patients repeatedly (>= 5 times) within a week. Based on the repeated evaluation results, the enrolled patients with prolonged DOC were divided into unresponsive wakefulness syndrome (UWS), minimally conscious state (MCS), and emergence from MCS (EMCS). Finally, the relationship between the results of the CRS-R and the clinical consensus were analyzed. Results: In this study, 137 patients with a clinical-consensus diagnosis of prolonged DOC were enrolled. It was found that 24.7% of patients with clinical UWS were actually in MCS after a single CRS-R behavior evaluation, while the repeated CRS-R evaluation results showed that the proportion of misdiagnosis of MCS was 38.2%. A total of 16.7% of EMCS patients were misdiagnosed with clinical MCS, and 1.1% of EMCS patients were misdiagnosed with clinical UWS. Conclusions: The rate of the misdiagnosis by clinical consensus is still relatively high. Therefore, clinicians should be aware of the importance of the bedside CRS-R behavior assessment and should apply the CRS-R tool in daily procedures.
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