4.8 Article

Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks

期刊

BMC MEDICINE
卷 18, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12916-020-01684-w

关键词

Digital pathology; Platinum response; Gene expression; Proteomics; Machine learning; Serous ovarian carcinoma

资金

  1. Schlager Family Award for Early Stage Digital Health Innovations
  2. Partners' Innovation Discovery Grant
  3. Blavatnik Center for Computational Biomedicine Award
  4. Harvard Data Science Fellowship

向作者/读者索取更多资源

Background Ovarian cancer causes 151,900 deaths per year worldwide. Treatment and prognosis are primarily determined by the histopathologic interpretation in combination with molecular diagnosis. However, the relationship between histopathology patterns and molecular alterations is not fully understood, and it is difficult to predict patients' chemotherapy response using the known clinical and histological variables. Methods We analyzed the whole-slide histopathology images, RNA-Seq, and proteomics data from 587 primary serous ovarian adenocarcinoma patients and developed a systematic algorithm to integrate histopathology and functional omics findings and to predict patients' response to platinum-based chemotherapy. Results Our convolutional neural networks identified the cancerous regions with areas under the receiver operating characteristic curve (AUCs) > 0.95 and classified tumor grade with AUCs > 0.80. Functional omics analysis revealed that expression levels of proteins participated in innate immune responses and catabolic pathways are associated with tumor grade. Quantitative histopathology analysis successfully stratified patients with different response to platinum-based chemotherapy (P = 0.003). Conclusions These results indicated the potential clinical utility of quantitative histopathology evaluation in tumor cell detection and chemotherapy response prediction. The developed algorithm is easily extensible to other tumor types and treatment modalities.

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