期刊
BMC BIOLOGY
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12915-020-00839-8
关键词
Ancient DNA; Egyptian mummified individuals; Metagenomics; Leprosy; Hepatitis B virus
类别
资金
- University of Zurich's University Research Priority Program Evolution in Action: From Genomes to Ecosystems
- Max Planck Society
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [845479]
- European Molecular Biology Organization (EMBO) long-term fellowship [ALTF 1086-2018]
- Marie Curie Actions (MSCA) [845479] Funding Source: Marie Curie Actions (MSCA)
Background Recent advances in sequencing have facilitated large-scale analyses of the metagenomic composition of different samples, including the environmental microbiome of air, water, and soil, as well as the microbiome of living humans and other animals. Analyses of the microbiome of ancient human samples may provide insights into human health and disease, as well as pathogen evolution, but the field is still in its very early stages and considered highly challenging. Results The metagenomic and pathogen content of Egyptian mummified individuals from different time periods was investigated via genetic analysis of the microbial composition of various tissues. The analysis of the dental calculus' microbiome identified Red Complex bacteria, which are correlated with periodontal diseases. From bone and soft tissue, genomes of two ancient pathogens, a 2200-year-oldMycobacterium lepraestrain and a 2000-year-old human hepatitis B virus, were successfully reconstructed. Conclusions The results show the reliability of metagenomic studies on Egyptian mummified individuals and the potential to use them as a source for the extraction of ancient pathogen DNA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据