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How to measure retinal microperfusion in patients with arterial hypertension

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BLOOD PRESSURE
卷 30, 期 1, 页码 4-19

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TAYLOR & FRANCIS LTD
DOI: 10.1080/08037051.2020.1823816

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Arterial hypertension; microperfusion; retinal microvasculature

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The assessment and monitoring of microcirculatory changes in arterial hypertension management is crucial, with a shift towards non-invasive methods focusing on the retinal vasculature. Various methods for measuring retinal microcirculation have been reviewed, with Scanning Laser Doppler Flowmetry being the most commonly used in studies of arterial hypertension, followed by Optical Coherence Tomography Angiography and retinal vasculature assessment software.
Purpose Assessment and monitoring of changes in microcirculatory perfusion, perfusion dynamic, vessel structure and oxygenation is crucial in management of arterial hypertension. Constant search for non-invasive methods has led the clinical focus towards the vasculature of the retina, which offers a large opportunity to detect the early phase of the functional and structural changes in the arterial hypertension and can reflect changes in brain vasculature. We review all the available methods of retinal microcirculation measurements including angiography, oximetry, retinal vasculature assessment software, Optical Coherence Tomography Angiography, Adaptive Optics and Scanning Laser Doppler Flowmetry and their application in clinical research. Materials and methods To further analyse the applicability of described methods in hypertension research we performed a systematic search of the PubMed electronic database (April 2020). In our analysis, we included 111 articles in which at least one of described methods was used for assessment of microcirculation of the retina in hypertensive individuals. Results Up to this point, the methods most commonly published in studies of retinal microcirculation in arterial hypertension were Scanning Laser Doppler Flowmetry followed shortly by Optical Coherence Tomography Angiography and retinal vasculature assessment software. Conclusions While none of described methods enables the simultaneous measurement of all microcirculatory parameters, certain techniques are widely used in arterial hypertension research, while others gain popularity in screening.

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