期刊
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 128, 期 5, 页码 827-836出版社
WILEY
DOI: 10.1111/1471-0528.16498
关键词
Epidemiology; general obstetrics; maternal physiology; medical disorders in pregnancy; placental pathology; risk management; translational research
资金
- Perinatal Epidemiological Research Initiative Program Grant from the March of Dimes Foundation [20FY01-38, 20FY04-37]
- Eunice Kennedy Shriver National Institute for Child Health and Human Development
- National Institute of Nursing Research [R01-HD34543]
- Thrasher Research Foundation [02816-7]
- Centers for Disease Control and Prevention [U01-DP000143-01]
- National Heart, Lung, and Blood Institute [R01-HL103825]
PE-related placental/extraplacental membrane findings can help identify women with moderately elevated blood pressure during pregnancy who are at increased risk for developing hypertension later in life. Placental findings are associated with the mother's risk of later-life hypertension.
Objective To assess whether pre-eclampsia (PE)-related placental/extraplacental membrane findings are linked to moderately elevated blood pressure (BP) in pregnancy and later-life hypertension. Design Prospective cohort. Setting 52 prenatal clinics, 5 Michigan communities. Sample The POUCH Study recruited women at 16-27 weeks' gestation (1998-2004) and studied a sub-cohort in depth. This sample (n = 490) includes sub-cohort women with detailed placental assessments and cardiovascular health evaluations 7-15 years later in the POUCHmoms follow-up study. Methods PE-related placental/extraplacental membrane findings (i.e. mural hyperplasia, unaltered/abnormal vessels or atherosis in decidua; infarcts) were evaluated in relation to pregnancy BP and odds of Stage 2 hypertension at follow up using weighted polytomous regression. Follow-up hypertension odds also were compared in three pregnancy BP groups: normotensives (referent) and moderately elevated BP with or without PE-related placental/extraplacental membrane findings. Main outcome measures Stage 2 hypertension (SBP >= 140 mmHg and/or DBP >= 90 mmHg, or using antihypertensive medications) at follow up. Results After excluding women with pregnancy hypertension (i.e. chronic, PE, gestational), mural hyperplasia and unaltered/abnormal decidual vessels were each associated with Stage 2 hypertension at follow up: adjusted odds ratio (aOR) = 2.7, 95% CI 1.1-6.6, and aOR = 1.7 (95% CI 0.8-3.4), respectively. Women with moderately elevated BP in pregnancy and evidence of mural hyperplasia or unaltered/abnormal decidual vessels had greater odds of Stage 2 hypertension at follow up: aOR = 4.5 (95% CI 1.6-12.5 and aOR = 2.6, 95% CI 1.1-5.9, respectively. Conclusions PE-related placental/extraplacental membrane findings help risk-stratify women with moderately elevated BP in pregnancy for later development of hypertension. Tweetable Abstract Placental findings associated with mother's risk of later-life hypertension.
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