期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 30, 期 17, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2020.127375
关键词
Trichothecene; Trichobreol; Trichoderma cf. brevicompactum; Antifungal activity; Candida albicans; Cryptococcus neoformans
资金
- JSPS KAKENHI [25870660, 16K21310, 16K15134]
Two new trichothecene sesquiterpenes, trichobreols D (1) and E (2), were isolated from the culture broth of marine-derived Trichoderma cf. brevicompactum together with trichobreol A (3). The structures of 1 and 2 were assigned on the basis of their spectroscopic data. Compound 1 inhibited the growth of two yeast-like fungi, Candida albicans and Cryptococcus neoformans, with equivalent MIC values (6.3 mu g/mL), while 2 gave MIC values of 12.5 and 25 mu g/mL, respectively. The antifungal activities of five semisynthetic derivatives (4-8) prepared from 3 were evaluated and compared to investigate the preliminary structure-activity relationship.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据