期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 130, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110624
关键词
Melaleuca alternifolia; Tea tree oil; Protozoa; Nematodes; Cestode; Monogenean parasites
资金
- Natural Science Foundation of China [81971955, 81471973]
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA
- Natural Science Foundation of Guangdong Province, China [2019A1515011667]
- Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, China [2020ZX02]
- undergraduate teaching quality engineering and teaching reform project of Sun Yat-sen University, China [2020/72]
Australian tea tree (Melaleuca alternifolia) oil (TTO) and its monoterpene constituents such as terpinen-4-ol (T4O), 1,8-cineole, limonene, p-cymene, and a-terpinene have been shown to be effective in controlling a wide range of parasitic infections. The anti-parasitic effects of these compounds are mainly due to their anti-histamine and anti-acetylcholinesterase activities as well as their ability to modulate host inflammatory responses. This review attempts to summarize recent advances in the uses of TTO and its 15 major monoterpene constituents in treating parasitic infections in both humans and animals. Activities against parasitic protozoans (Plasmodium falciparum, Leishmania spp., Trypanosoma spp., Acanthamoeba castellanii, Trichomonas vaginalis, Eimeria, and Ichthyophthirius multifiliis), nematodes (Haemonchus contortus and Anisakis simplex), cestode (Echinococcus ortleppi), and monogeneans (Gasterosteus spp. and Dactylogyrus minutus) have been reported, showing good potentials in treating parasitic infections. Further studies are necessary for developing anti-parasite therapies using TTO or its monoterpenes constituents.
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