期刊
BIOMATERIALS
卷 255, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120176
关键词
Hyaluronate-collagen hydrogel; Bio-orthogonal; SPAAC crosslinking; Corneal wound repair; Sutureless repair; Cornea substitute
资金
- National Institutes of Health (National Eye Institute) [K08EY028176]
- National Institutes of Health (Departmental core grant) [P30EY026877]
- Stanford SPARK Translational Research Grant
- Research to Prevent Blindness (RPB)
- Matilda Ziegler Foundation
- VA Rehabilitation Research and Development Small Projects in Rehabilitation Effectiveness (SPiRE) program [I21 RX003179]
- Byers Eye Institute at Stanford
- National Science Foundation [DMR 1808415, ECCS-1542152]
Biomaterials that mimic corneal stroma could decrease the need for donor corneal tissue and could decrease the prevalence of complications associated with corneal transplantation, including infection and rejection. We developed a bio-orthogonally crosslinked hyaluronate-collagen hydrogel which can fill corneal defects in situ without the need for any sutures, initiators, or catalysts. We studied the effects of biorthogonal crosslinking on the light transmittance of the hydrogel, which was greater than 97% water. The transmittance of the optimized hydrogel in the visible light range was over 94%. We also investigated the mechanical properties, refractive index, morphology, biocompatibility, and corneal re-epithelialization capacity of the hyaluronate-collagen hydrogel. Our in vitro, in vivo, and ex vivo results demonstrated that this bio-orthogonally crosslinked hyaluronatecollagen hydrogel has excellent potential as a biomaterial for cornea repair and regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据