期刊
BIOMATERIALS
卷 269, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120459
关键词
NIR-II; Inorganic; Photothermal; Nanotheranostics
资金
- NTU [M4081851]
- Ministry of Education of Singapore Tier 3 grant [MOE 2016-T3-1-004]
The emergence of NIR-II activated photomedicines has significantly expanded the penetration depth for noninvasive theranostics; However, there is a lack of thorough review for NIR-II inorganic PTAs, with most comparisons made with NIR-I PTAs; This review aims to inspire further development of NIR-II activated inorganic PTAs with good photothermal conversion ability and potential biomedical applications.
The emergence of near-infrared-II (NIR-II) activated photomedicines has extended the penetration depth for noninvasive theranostics, especially for photothermal nanomedicines. The current early development stage for NIR-II activated photomedicines has focused on creating a greater variety of photothermal agents (PTAs) with superior photothermal conversion ability. However, there is no thorough review for NIR-II inorganic PTAs and most comparisons of the photothermal performances of NIR-II inorganic PTAs are made with NIR-I PTAs. This review will first discuss about the key mechanisms of NIR-II absorption and photothermal conversion. Subsequently, this review will summarize recently developed advanced NIR-II inorganic PTAs based on the dominant inorganic elements and provide a comparison of their NIR-II photothermal performances. The nanostructure design, enhancement strategies and potential biomedical applications will be listed and discussed. We hope this review will further inspire active development and study of NIR-II activated inorganic PTAs with good photothermal conversion ability, multifunctionality, biocompatibility or biodegradability, and disease targeting ability.
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