期刊
BIOINFORMATICS
卷 37, 期 12, 页码 1739-1746出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa907
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类别
资金
- Japan Society for the Promotion of Science KAKENHI [17K12741, 20K11962]
- Grants-in-Aid for Scientific Research [17K12741, 20K11962] Funding Source: KAKEN
This study introduces a new method for extracting drug-drug interactions (DDIs) from literature, utilizing external drug database information and large-scale plain text. The results demonstrate that integrating large-scale raw text information can greatly improve DDI extraction performance, while simultaneously using drug description and molecular structure information can significantly enhance performance across all DDI types. The effective combination of plain text, drug description, and molecular structure information is essential for improving DDI extraction.
Motivation: Neural methods to extract drug-drug interactions (DDIs) from literature require a large number of annotations. In this study, we propose a novel method to effectively utilize external drug database information as well as information from large-scale plain text for DDI extraction. Specifically, we focus on drug description and molecular structure information as the drug database information. Results: We evaluated our approach on the DDIExtraction 2013 shared task dataset. We obtained the following results. First, large-scale raw text information can greatly improve the performance of extracting DDIs when combined with the existing model and it shows the state-of-the-art performance. Second, each of drug description and molecular structure information is helpful to further improve the DDI performance for some specific DDI types. Finally, the simultaneous use of the drug description and molecular structure information can significantly improve the performance on all the DDI types. We showed that the plain text, the drug description information and molecular structure information are complementary and their effective combination is essential for the improvement.
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