期刊
BIOINFORMATICS
卷 37, 期 6, 页码 882-884出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa755
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资金
- Swiss National Science Foundation (SNF) Ambizione [180010]
STACAS is a computational method that can accurately align scRNA-seq datasets composed of partially overlapping cell populations by correcting batch effects, filtering aberrant integration anchors with a quantitative distance measure, and constructing optimal guide trees for integration.
STACAS is a computational method for the identification of integration anchors in the Seurat environment, optimized for the integration of single-cell (sc) RNA-seq datasets that share only a subset of cell types. We demonstrate that by (i) correcting batch effects while preserving relevant biological variability across datasets, (ii) filtering aberrant integration anchors with a quantitative distance measure and (iii) constructing optimal guide trees for integration, STACAS can accurately align scRNA-seq datasets composed of only partially overlapping cell populations.
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