期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1868, 期 9, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbapap.2020.140449
关键词
D-Serine; Chronic kidney disease; Acute kidney injury; Glomerular filtration rate; Intra-body dynamics; Urinary excretion; Biomarker
资金
- Japan Society for the Promotion of Science (JSPS) [17H04188]
- Japan Agency of Medical Research and Development (AMED) [JP19gm5010001]
- Miraca Research Institute
- Osaka Kidney Bank
- Grants-in-Aid for Scientific Research [17H04188] Funding Source: KAKEN
D-Serine, a long-term undetected enantiomer of serine, is now showing its potential as a biomarker for kidney diseases. The intra-body dynamics of D-serine, currently defined by blood levels and urinary excretion dynamics, are useful for a comprehensive assessment of kidney function and disease activity. Thus, widespread adoption of D-serine as a biomarker can resolve the long-standing clinical challenge of the early detection and prognostic prediction of kidney diseases. Accuracy and reliability of the measurements are particularly important because these measurements will affect treatment decisions and thus impact the patient's emotional state and quality of life. Accordingly, this review focuses on current clinical challenges in kidney diseases and the potential for monitoring of D-serine to overcome these issues, and discuss the requirements of accurate quantification.
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