期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1862, 期 9, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2020.183356
关键词
Solution NMR spectroscopy; Structural biology; Integral membrane proteins; Protein expression; Isotope labeling; Membrane mimetics
资金
- NSERC (Natural Sciences and Engineering Research Council of Canada) [RGPIN-2015-06664]
- CIHR (Canadian Institutes of Health Research) Phase 2 Clinician Scientist Salary Award
Integral membrane proteins (IMPs) perform unique and indispensable functions in the cell, making them attractive targets for fundamental research and drug discovery. Developments in protein production, isotope labeling, sample preparation, and pulse sequences have extended the utility of solution NMR spectroscopy for studying IMPs with multiple transmembrane segments. Here we review some recent applications of solution NMR for studying structure, dynamics, and interactions of polytopic IMPs, emphasizing strategies used to overcome common technical challenges.
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