期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1862, 期 9, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2020.183299
关键词
Junctional adhesion molecules (JAMs); Epithelial cell; Tight junction; Polarity
资金
- German Research Foundation [EB 160/5-1, EB160/7-1, EXC-1003 FF-2016-01]
- Medical Faculty of the University Munster [IZKF Eb2/020/14]
Junctional adhesion molecules (JAMs) comprise a small subfamily of the immunoglobulin superfamily of adhesion receptors with a multitude of physiological functions in vertebrate development and homeostasis. Several members of the JAM family localize at tight junctions of epithelial and endothelial cells where they interact with PDZ domain-containing scaffolding proteins. For some JAM family members, molecular mechanisms have been elaborated through which they regulate cell-cell contact maturation and tight junction formation. For other members of this family our knowledge on their role in barrier-forming epithelia is still fragmentary. Here, we review our current understanding of the contribution of JAM family proteins to the barrier function of epithelial and endothelial cells with a major focus on epithelial tight junctions.
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