相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
Travis W. Grim et al.
NEUROPSYCHOPHARMACOLOGY (2020)
G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder
Anna M. Gutridge et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
A Novel G Protein-Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain
Alexandra E. Conibear et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2020)
Morphine-induced respiratory depression is independent of β-arrestin2 signalling
Andrea Kliewer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected lndole-Based Kratom Alkaloids
Samuel Obeng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor
Rachel S. Crowley et al.
ACS CHEMICAL NEUROSCIENCE (2020)
Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells
Miriam Stoeber et al.
ELIFE (2020)
Biased signaling by endogenous opioid peptides
Ivone Gomes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Quantification of observable behaviors induced by typical and atypical kappa-opioid receptor agonists in male rhesus monkeys
S. L. Huskinson et al.
PSYCHOPHARMACOLOGY (2020)
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Reid H. J. Olsen et al.
NATURE CHEMICAL BIOLOGY (2020)
Evaluation of Biased and Balanced Salvinorin A Analogs in Preclinical Models of Pain
Kelly F. Paton et al.
FRONTIERS IN NEUROSCIENCE (2020)
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions
Lloyd D. Fricker et al.
MOLECULAR PHARMACOLOGY (2020)
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine
Scott E. Hemby et al.
ADDICTION BIOLOGY (2019)
Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion
Jeffrey J. Liu et al.
NEUROPSYCHOPHARMACOLOGY (2019)
Bifunctional opioid receptor ligands as novel analgesics
Christopher W. Cunningham et al.
NEUROPHARMACOLOGY (2019)
Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry
Abhisheak Sharma et al.
DRUG TESTING AND ANALYSIS (2019)
The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats
Takato Hiranita et al.
PSYCHOPHARMACOLOGY (2019)
7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
Andrew C. Kruegel et al.
ACS CENTRAL SCIENCE (2019)
Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs
Jordan K. Zjawiony et al.
FRONTIERS IN PSYCHIATRY (2019)
A Biased View of μ-Opioid Receptors?
Alexandra E. Conibear et al.
MOLECULAR PHARMACOLOGY (2019)
Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)
Shyam H. Kamble et al.
XENOBIOTICA (2019)
Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
A. Kliewer et al.
NATURE COMMUNICATIONS (2019)
A review of salvinorin analogs and their kappa-opioid receptor activity
Jeremy J. Roach et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
O6C-20-nor-salvinorin A is a stable and potent KOR agonist
Shun Hirasawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
In vivo effects of -opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration
Jessica P. Anand et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
The novel mu-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception
Rob Hill et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Tolerance to high-internalizing opioid receptor agonist is critically mediated by arrestin 2
Ana Vicente-Sanchez et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Tao Che et al.
CELL (2018)
Strategy for making safer opioids bolstered
Susruta Majumdar et al.
NATURE (2018)
Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels-Alder Strategy
Yuzhou Wang et al.
ORGANIC LETTERS (2018)
Structure of the μ-opioid receptor-Gi protein complex
Antoine Koehl et al.
NATURE (2018)
Abuse liability of mitragynine assessed with a self-administration procedure in rats
Kai Yue et al.
PSYCHOPHARMACOLOGY (2018)
Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents
Bronwyn M. Kivell et al.
MOLECULES (2018)
Allostery at opioid receptors: modulation with small molecule ligands
Kathryn E. Livingston et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
The analgesic and anti-inflammatory effects of Salvinorin A analogue -tetrahydropyran Salvinorin B in mice
K. F. Paton et al.
EUROPEAN JOURNAL OF PAIN (2017)
Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability
Alexander M. Sherwood et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands
Alexander M. Sherwood et al.
ORGANIC LETTERS (2017)
The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects
Amy W. M. Ewald et al.
PSYCHOPHARMACOLOGY (2017)
Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist
Jeremy J. Roach et al.
ACS CENTRAL SCIENCE (2017)
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice
Mariana Spetea et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake
T. Chiang et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Total Synthesis of (-)-Salvinorin A
Nathan J. Line et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability
Rachel Saylor Crowley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
Andras Varadi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2016)
Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function
Amynah A. Pradhan et al.
JOURNAL OF NEUROSCIENCE (2016)
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
Andrew C. Kruegel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik et al.
NATURE (2016)
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity
Achla Gupta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Tarsis F. Brust et al.
SCIENCE SIGNALING (2016)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Tarsis F. Brust et al.
SCIENCE SIGNALING (2016)
Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior
Andras Varadi et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists
David Y. W. Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors
Kelly M. DiMattio et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
Structural insights into μ-opioid receptor activation
Weijiao Huang et al.
NATURE (2015)
Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders (vol 6, 190, 2015)
Eduardo R. Butelman et al.
FRONTIERS IN PHARMACOLOGY (2015)
Pharmacology and anti-addiction effects of the novel kappa opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A
B. Simonson et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor
Prabhakar R. Polepally et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Opiate Pharmacology and Relief of Pain
Gavril W. Pasternak
JOURNAL OF CLINICAL ONCOLOGY (2014)
Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues
Andrew P. Riley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism
Bronwyn Kivell et al.
NEUROPHARMACOLOGY (2014)
Psychiatric agents and implications for perioperative analgesia
Blas Catalani et al.
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY (2014)
Orally Active Opioid μ/δ Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice
Kenjiro Matsumoto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds
Kate L. White et al.
MOLECULAR PHARMACOLOGY (2014)
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands
Prabhakar R. Polepally et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Orally Active Opioid Compounds from a Non-Poppy Source
Robert B. Raffa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects
Katherine A. MacLean et al.
PSYCHOPHARMACOLOGY (2013)
Mu Opioids and Their Receptors: Evolution of a Concept
Gavril W. Pasternak et al.
PHARMACOLOGICAL REVIEWS (2013)
Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans
Mohini Ranganathan et al.
BIOLOGICAL PSYCHIATRY (2012)
Semisynthetic neoclerodanes as kappa opioid receptor probes
Kimberly M. Lovell et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues
Cecile Beguin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Ligand-directed signalling within the opioid receptor family
Amynah A. Pradhan et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Total syntheses of mitragynine, paynantheine and speciogynine via an enantioselective thiourea-catalysed Pictet-Spengler reaction
Isabel P. Kerschgens et al.
CHEMICAL COMMUNICATIONS (2012)
Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology: From a symposium on new concepts in mu-opioid pharmacology
Kenneth Lamb et al.
DRUG AND ALCOHOL DEPENDENCE (2012)
Mitragyna speciosa, A Psychoactive Tree from Southeast Asia with Opioid Activity
Jessica E. Adkins et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum
Matthew W. Johnson et al.
DRUG AND ALCOHOL DEPENDENCE (2011)
Opioid Receptor Probes Derived from Cycloaddition of the Hallucinogen Natural Product Salvinorin A
Anthony Lozama et al.
JOURNAL OF NATURAL PRODUCTS (2011)
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
Kirsten M. Raehal et al.
NEUROPHARMACOLOGY (2011)
Pharmacological activity of Salvinorin A, the major component of Salvia divinorum
Joanna Listos et al.
PHARMACOLOGICAL REPORTS (2011)
Neuropharmacology of the Naturally Occurring κ-Opioid Hallucinogen Salvinorin A
Christopher W. Cunningham et al.
PHARMACOLOGICAL REVIEWS (2011)
Functional Selectivity at the μ-Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance
Kirsten M. Raehal et al.
PHARMACOLOGICAL REVIEWS (2011)
Potential drug abuse therapeutics derived from the hallucinogenic natural product salvinorin A
Katherine M. Prevatt-Smith et al.
MEDCHEMCOMM (2011)
Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A
David Y. W. Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Kappa opioids and the modulation of pain
Bronwyn Kivell et al.
PSYCHOPHARMACOLOGY (2010)
Kinase cascades and ligand-directed signaling at the kappa opioid receptor
Michael R. Bruchas et al.
PSYCHOPHARMACOLOGY (2010)
Hagemann's ester: a timeless building block for natural product synthesis
Gian Piero Pollini et al.
TETRAHEDRON (2010)
Structure-Based Design, Synthesis, and Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor
Feng Yan et al.
BIOCHEMISTRY (2009)
Modification of the furan ring of salvinorin A: Identification of a selective partial agonist at the kappa opioid receptor
Cecile Beguin et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
General Approach to the Total Synthesis of 9-Methoxy-Substituted Indole Alkaloids: Synthesis of Mitragynine, as well as 9-Methoxygeissoschizol and 9-Methoxy-Nb-methylgeissoschizol
Jun Ma et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
Benjamin B. Land et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
Jesse W. -H. Li et al.
SCIENCE (2009)
Second-generation synthesis of salvinorin A
Hisahiro Hagiwara et al.
TETRAHEDRON (2009)
In vitro stability and metabolism of salvinorin A in rat plasma
K. Tsujikawa et al.
XENOBIOTICA (2009)
Standard protecting groups create potent and selective κ opioids:: Salvinorin B alkoxymethyl ethers
Thomas A. Munro et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Herkinorin analogues with differential β-arrestin-2 interactions
Kevin Tidgewell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
Jacob M. Hooker et al.
NEUROIMAGE (2008)
MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine:: A novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice
Kenjiro Matsumoto et al.
NEUROPHARMACOLOGY (2008)
Intramolecular Diels-Alder/Tsuji allylation assembly of the functionalized trans-decalin of salvinorin A
Aaron C. Burns et al.
ORGANIC LETTERS (2008)
Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A
Masato Nozawa et al.
ORGANIC LETTERS (2008)
2-methoxymethyl-salvinorin B is a potent κ opioid receptor agonist with longer lasting action in vivo than salvinorin A
Yulin Wang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
N-methylacetamide analog of salvinorin A: A highly potent and selective kappa-opioid receptor agonist with oral efficacy
Cecile Beguin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Stress-induced p38 mitogen-activated protein kinase activation mediates κ-opioid-dependent dysphoria
Michael R. Bruchas et al.
JOURNAL OF NEUROSCIENCE (2007)
Total synthesis of the opioid agonistic indole alkaloid mitragynine and the first total syntheses of 9-methoxygeissoschizol and 9-Methoxy-Nb-methylgeissoschizol
Jun Ma et al.
ORGANIC LETTERS (2007)
β-arrestin-biased ligands at seven-transmembrane receptors
Jonathan D. Violin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Revised structure of deacetyl-1,10-didehydrosalvinorin G
Zhongze Ma et al.
TETRAHEDRON LETTERS (2007)
Synthetic studies of neoclerodane diterpenes from Salvia divinorum:: Preparation and opioid receptor activity of salvinicin analogues
Denise S. Simpson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Asymmetric synthesis of salvinorin A, a potent κ opioid receptor agonist
Jonathan R. Scheerer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B
Ruslan V. Blkbulatov et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
8-epi-Salvinorin B:: crystal structure and affinity at the κ opioid receptor
Thomas A. Munro et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2007)
75 years of opioid research: the exciting but vain quest for the Holy Grail
AD Corbett et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
New procedure to mask the 2,3-π bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a corynanthe skeleton
Hiromitsu Takayama et al.
ORGANIC LETTERS (2006)
Neo-clerodane diterpenes from the hallucinogenic sage Salvia divinorum
Osamu Shirota et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Involvement of μ-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa
Kenjiro Matsumoto et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Synthesis and in vitro pharmacological studies of new C(4) modified salvinorin A analogues
David Y. W. Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
The antinociceptive effect of Salvinorin A in mice
Trentini F. John et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Synthesis and in vitro evaluation of salvinorin A analogues:: Effect of configuration at C(2) and substitution at C(18)
Cecile Beguin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Synthesis of salvinorin A analogues as opioid receptor probes
Kevin Tidgewell et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Partial agonistic effect of 9-hydroxycorynantheidine on μ-opioid receptor in the guinea-pig ileum
K Matsumoto et al.
LIFE SCIENCES (2006)
Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats
WA Carlezon et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Opioid Ligands with mixed mu/delta opioid receptor interactions: An emerging approach to novel analgesics
S Ananthan
AAPS JOURNAL (2006)
Studies towards the synthesis of Salvinorin A
Anthony R. Lingham et al.
AUSTRALIAN JOURNAL OF CHEMISTRY (2006)
Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist
CR McCurdy et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa
K Matsumoto et al.
LIFE SCIENCES (2005)
New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human κ opioid receptors
DYW Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues
DYW Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues
DYW Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands
WW Harding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum
WW Harding et al.
ORGANIC LETTERS (2005)
Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to κ-opioid receptors
F Yan et al.
BIOCHEMISTRY (2005)
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2)
C Béguin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Determination of Salvinorin A in body fluids by high performance liquid chromatography - Atmospheric pressure chemical ionization
MS Schmidt et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)
Studies toward the pharmacophore of salvinorin A, a potent κ opioid receptor agonist
TA Munro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Morphine side effects in beta-arrestin 2 knockout mice
KM Raehal et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: A powerful and convenient mixed anhydride method promoted by basic catalysts
I Shiina et al.
JOURNAL OF ORGANIC CHEMISTRY (2004)
Antinociceptive effect of 7-hydroxymitragynine in mice:: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa
K Matsumoto et al.
LIFE SCIENCES (2004)
Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum is a highly efficacious κ-opioid receptor agonist:: Structural and functional considerations
C Chavkin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa
H Takayama
CHEMICAL & PHARMACEUTICAL BULLETIN (2004)
Agonist-induced regulation and trafficking of κ opioid receptors
LY Liu-Chen
LIFE SCIENCES (2004)
Kappa opioid agonists suppress chloroquine-induced scratching in mice
S Inan et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
A facile method for the preparation of deuterium labeled salvinorin A:: synthesis of [2,2,2-2H3]-salvinorin A
K Tidgewell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum
AK Bigham et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A
TA Munro et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor
DJ Sheffler et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2003)
A novel and efficient macrolactonization of ω-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride (MNBA)
I Shiina et al.
TETRAHEDRON LETTERS (2002)
Salvinorin A:: A potent naturally occurring nonnitrogenous κ opioid selective agonist
BL Roth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands
H Takayama et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Salvinorin C, a new neoclerodane diterpene from a bioactive fraction of the hallucinogenic Mexican mint Salvia divinorum
LJ Valdes et al.
ORGANIC LETTERS (2001)
Fungal metabolites.: Part 45:: The sesquiterpenes of Collybia maculata and Collybia peronata
F Castronovo et al.
TETRAHEDRON (2001)