期刊
BIOCHEMISTRY
卷 60, 期 18, 页码 1381-1400出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.0c00629
关键词
-
资金
- NIH [DA045884, DA046487, DA048379]
- Center for Clinical Pharmacology, St. Louis College of Pharmacy
- Washington University
Pain management has been a significant issue in medicine, with efforts focused on developing alternative opioids without side effects.
Pain remains a very pervasive problem throughout medicine. Classical pain management is achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which have significant side effects that hinder their utility. Pharmacologists have been trying to develop opioids devoid of side effects since the isolation of morphine from papaver somniferum, more commonly known as opium by Sertiirner in 1804. The natural products salvinorin A, mitragynine, and collybolide represent three nonmorphinan natural product-based targets, which are potent selective agonists of opioid receptors, and emerging next-generation analgesics. In this work, we review the phytochemistry and medicinal chemistry efforts on these templates and their effects on affinity, selectivity, analgesic actions, and a myriad of other opioid-receptor-related behavioral effects.
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