期刊
BIOCHEMICAL JOURNAL
卷 477, 期 19, 页码 3649-3672出版社
PORTLAND PRESS LTD
DOI: 10.1042/BCJ20200064
关键词
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资金
- Danish Cancer Society Grant Kraeftens Bekaempelses Videnskabelige Udvalg (KBVU) Grant [R146-A9414, R231-A13855]
- Novo Nordisk Fonden [52550]
- Associazione Italiana per la Ricerca sul Cancro (AIRC) Grant [IG20719]
- Danish National Research Foundation [DNRF125]
S-nitrosylation, the post-translational modification of cysteines by nitric oxide, has been implicated in several cellular processes and tissue homeostasis. As a result, alterations in the mechanisms controlling the levels of S-nitrosylated proteins have been found in pathological states. In the last few years, a role in cancer has been proposed, supported by the evidence that various oncoproteins undergo gain- or loss-of-function modifications upon S-nitrosylation. Here, we aim at providing insight into the current knowledge about the role of S-nitrosylation in different aspects of cancer biology and report the main anticancer strategies based on: (i) reducing S-nitrosylation-mediated oncogenic effects, (ii) boosting S-nitrosylation to stimulate cell death, (iii) exploiting S-nitrosylation through synthetic lethality.
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