期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 531, 期 4, 页码 595-601出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.07.088
关键词
Cortistatin; Asthma; CCL2; NF-kappa B; Inflammation
资金
- Natural Science Foundation of Shandong Province [BS2015SW028, ZR2016HM53, ZR2019MH05]
- Key Research and Development Projects of Shandong Province [2015GSF118115]
- Cross-disciplinary Fund of Shandong University [2018JC007]
- National Natural Science Foundation of China [81572191, 81501880, 81602761]
Asthma is a chronic inflammatory disease affecting millions of people around the world, yet much remains unknown about its underlying mechanisms. Cortistatin (CST) is a neuropeptide which is reported to be a potential endogenous anti-inflammatory factor in several conditions. To testify the potential involvement of CST in airway inflammatory reaction, an ovalbumin (OVA)-induced mice model was established in wild-type (WT) as well as CST-knockout (Cort(-/-)) mice. Thereafter, lung tissue or cell samples were gathered in each group, and histological analysis as well as cell counting assay indicated that Cort(-/-) mice exhibited exaggeration of asthma compared with WT control group. Moreover, mRNA sequencing assay revealed that CCL2 was a potential target of CST in asthma, and administration of CCL2 inhibitor alleviated airway inflammation of asthma in Cort(-/-) mice. Moreover, NF-kappa B signaling pathway might be closely associated with the protective function of CST in asthma, as enhanced activation of NFkB signaling pathway was observed in OVA-induced asthma model of Cort(-/-) mice, and SN50, an inhibitor of NF-kappa B signaling pathway, antagonized asthma development in Cort(-/-) mice. In summary, CST might represent as a promising target for the treatment of asthma through interacting with CCL2 and NF-kappa B signaling pathway. (C) 2020 Elsevier Inc. All rights reserved.
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