期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 16, 期 -, 页码 2272-2281出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.16.188
关键词
ball milling; boronic ester; dextran; bodipy; nanoparticles
资金
- MIUR-Italy
- National Science Centre of Poland [OPUS : 2019/33/B/ST5/01495]
Mechanochemistry is an emerging and reliable alternative to conventional solution (batch) synthesis of complex molecules under green and solvent-free conditions. In this regard, we report here on the conjugation of a dextran polysaccharide with a fluorescent probe, a phenylboronic acid (PBA)-functionalized boron dipyrromethene (BODIPY) applying the ball milling approach. The ball milling formation of boron esters between PBA BODIPY and dextran proved to be more efficient in terms of reaction time, amount of reactants, and labelling degree compared to the corresponding solution-based synthetic route. PBA-BODIPY dextran assembles into nanoparticles of around 200 nm by hydrophobic interactions. The resulting PBA-BODIPY dextran nanoparticles retain an apolar interior as proved by pyrene fluorescence, suitable for the encapsulation of hydrophobic drugs with high biocompatibility while remaining fluorescent.
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