期刊
COMPTES RENDUS BIOLOGIES
卷 339, 期 7-8, 页码 319-323出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crvi.2016.04.008
关键词
Quantitative metagenomics; Microbial gene catalog; Microbial communities; Dysbiosis; Chronic disease prevention
类别
资金
- Metagenopolis grant [ANR-11-DPBS-0001]
The human gut microbiome can now be characterized in unprecedented detail by an approach based on high-throughput sequencing of total stool DNA, that we name quantitative metagenomics. Central to the approach is a catalog that lists all the genes of intestinal microbes that are known -9.9 millions, identified by the analysis of 1267 stool samples. Beyond the gene list, genetic units that carry them begun to be known; many of these correspond to bacterial species that were never isolated and cultured yet. Quantitative metagenomics allows developing powerful algorithms to diagnose a disease, monitor patients and identify individuals at risk to progress towards a disease. This lays ground for developing new approaches to better restore and even preserve the health by modulation of the altered microbiome, which contributes to promote or aggravate a disease. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS.
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